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The biological hallmarks of aging are a set of molecular and cellular damage processes that accumulate over time, leading to the functional decline and increased susceptibility to disease that characterize aging. These hallmarks were first described by Lopez-Otin et al. in 2016 and later expanded upon by Kennedy et al. in 2017. They can be categorized into nine primary hallmarks and four integrative hallmarks. Here, we describe the primary hallmarks of aging:
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